Clobevate Cream: Uses, Side Effects, and Price in Pakistan

Clobetasol propionate cream, or Clobevate cream, is a topical corticosteroid medication used to treat various skin conditions, such as eczema, psoriasis, dermatitis, and allergic reactions. It works by reducing inflammation, itching, and redness in the affected skin areas.

Marketed By: GlaxoSmithKline (GSK) 

Drug Class: Corticosteroid

Generic: Clobetasol Propionate

Product Form: Cream 

Mechanism of Action: 

Clobetasol propionate, the active ingredient in Clobevate cream, is a potent synthetic corticosteroid that works by binding to glucocorticoid receptors in the skin cells. This binding activates the receptor, leading to the production of anti-inflammatory proteins that help reduce inflammation, itching, and redness in the affected skin areas. 

Available strengths

• Clobevate cream 0.05%

What is Price of Clobevate cream in Pakistan?

Clobevate cream price in Pakistan ranges between 120-150 PKR per 20gm pack. The Clobevate cream price varies depending on the strength and manufacturer.

What is Clobevate cream Used for?

Clobevate cream uses include;

1. Psoriasis: Clobevate cream can be used to treat psoriasis, a chronic skin condition characterized by the buildup of skin cells that form scales and red patches. The cream works by reducing inflammation and suppressing the immune response, which helps to slow down the growth of skin cells and alleviate symptoms.
2. Eczema: It is also used to treat eczema, a condition that causes the skin to become red, itchy, and inflamed. It functions as relieving itching, which helps to improve the appearance and comfort of the affected area.
3. Dermatitis: Clobevate cream is also used to treat dermatitis, a condition characterized by inflammation of the skin. It helps to reduce inflammation and relieve symptoms such as redness, swelling, and itching.

Read more: Eczema Treatment In Pakistan 

How to apply Clobevate cream?

Follow these general guidelines for applying the Clobevate cream:

• Wash and dry the affected skin area before applying the cream.
• Squeeze a small amount of the cream onto your fingertips and apply a thin layer to the affected area.
• Rub the cream gently into the skin until it is completely absorbed.
• Do not cover the treated area with a bandage or dressing.
• Wash your hands after applying the cream.
• Apply the cream at the same time(s) each day to maintain a consistent level of medication in your body.
• Do not apply more than the recommended amount of cream or use it for longer than prescribed by your dermatologist.

What is Clobevate cream dosage?

The usual recommended dose for adults is a thin layer of Clobevate cream applied to the affected area twice daily. While the dosage of Clobevate cream in children should be decided by a dermatologist.

Also Read: Glycolic acid cream uses

What are Clobevate cream side effects?

Common side effects may include:

• Burning or stinging sensation on the skin
• Itching
• Dryness
• Redness
• Irritation
• Acne
• Skin thinning
• Stretch marks
• Discoloration of the skin

In rare cases, Clobevate cream may cause more severe side effects, such as:

• Allergic reactions, including swelling of the face, tongue, or throat, hives, and difficulty breathing
• Skin infection or worsening of the existing skin condition
• Adrenal suppression, which can occur with prolonged use or overuse of the medication, leads to decreased levels of cortisol in the body

If you experience any unusual symptoms or side effects, consult a dermatologist immediately.

What are the warnings associated with Clobevate cream?

The precautions and warnings associated with Clobevate cream use include;

• If you are allergic to clobetasol or any of the ingredients in Clobevate cream, do not use the medication. 
• Prolonged use of Clobevate cream can cause skin thinning, making it more susceptible to injury and infection.
• Clobevate cream is for external use only.

Does Clobevate cream react with medicines?

Some medications that may interact with Clobevate cream include:

• Oral corticosteroids
• Immunomodulators such as tacrolimus or pimecrolimus
• Warfarin
• Aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs)
• Antifungal medications

Also, read about the Best Skin Allergy Creams in Pakistan

Is Clobevate cream safe during Pregnancy?

Clobevate cream is classified as a pregnancy category C medication, which means that it may not be safe for use during pregnancy. 

Animal studies have revealed negative effects on fetal development, but adequate and well-controlled trials in pregnant women have not been conducted.

The active ingredient in Clobevate cream can pass into breast milk and may harm a nursing infant. Therefore, you should also talk to your gynecologist before using Clobevate cream if you are breastfeeding.

What are the alternatives to Clobevate cream?

The major alternatives to Clobevate cream include;

• Hydrocortisone cream
• Betamethasone cream
• Calcineurin inhibitors
• Salicylic acid
• Topical retinoids

What happens with Clobevate cream Overdose?

Overdosing on Clobevate cream may lead to an increased risk of side effects, especially if the medication is used for a prolonged period or in large amounts. 

If you suspect an overdose of Clobevate cream, consult with a dermatologist immediately. Treatment may involve discontinuing the medication, applying topical emollients or moisturizers to the affected area, or using other medications to treat the symptoms.

What happens if you miss the Clobevate cream dose?

Use the Clobevate cream as soon as you recall if you forget to use it. If your next dose is coming up soon, skip the missed one and follow your regular dosing schedule. Applying more medication to make up for a missed dose is not recommended.

How to store Clobevate cream dose?

Follow these instructions to store Clobevate cream:

• It should be stored at room temperature, away from heat and moisture. 
• Keep the cream out of reach of children and pets.
• Do not freeze the cream or store it in the bathroom, as moisture can cause the cream to degrade and lose its effectiveness. 
• Avoid exposing the cream to direct sunlight or extreme temperatures, such as in a car on a hot day.
• Do not use Clobevate cream if it has expired or if the packaging is damaged or shows signs of tampering.

Consult with a dermatologist to discuss any concerns or questions you have about using Clobevate cream.

FAQs:

1. Can you use Clobevate cream on your face for acne?

Using Clobevate cream on the face for acne may cause skin thinning, discoloration, and other side effects. It may also worsen certain skin conditions, such as acne, by causing or aggravating pimples or other breakouts.

2. How long does Clobevate take to work?

When used to treat eczema, clobetasol propionate typically takes one to three days to begin working. Within this period, there should be some improvement in symptoms including inflammation (redness) and itching.