Brexin Tablet: Uses, Side Effects & Price in Pakistan

Brexin tablet is an FDA-approved medicine that reduces the symptoms of musculoskeletal pain and inflammation, especially caused by different types of arthritis. It contains piroxicam-beta-cyclodextrin as an active ingredient, 

Manufactured by: Chiesi Pharmaceuticals (Pvt) Ltd

Generic: Piroxicam-beta-cyclodextrin

Drug class: Non-steroidal anti-inflammatory drugs (NSAIDs)

Product form: Oral tablet

Mechanism of Action of Piroxicam-beta-Cyclodextrin 

Piroxicam-beta-Cyclodextrin works by inhibiting the production of prostaglandins, which cause inflammation and pain. This is achieved by blocking the action of the enzyme cyclooxygenase (COX). By reducing the production of prostaglandins, piroxicam-beta-cyclodextrin helps to relieve pain, reduce inflammation, and lower fever.

Available Strength

Brexin Tablet 20mg

What is the Brexin tablet price in Pakistan?

Brexin tablet price in Pakistan ranges between 20-25 PKR per tablet and may vary depending upon the manufacturer chosen.

What is the Brexin tablet used for?

Brexin is used for;

• Osteoarthritis: Brexin is commonly used to treat the pain and inflammation caused by the degeneration of cartilage and other tissues due to osteoarthritis.
• Rheumatoid arthritis: Brexin tablet help reduce the pain and inflammation caused by rheumatoid arthritis, especially in older adults.
• Ankylosing spondylitis: This NSAID tablet is often used to treat the symptoms of ankylosing spondylitis such as back pain, early morning spine stiffness, or a stooped posture.
• Dysmenorrhea: Piroxicam promotes painless menstruation by effectively alleviating the pain associated with menstrual cramps or dysmenorrhea.
• Acute gout: Brexin is often used to relieve joint pain and inflammation caused by acute gout, especially in the elderly. 
• Pain relief: This tablet also helps reduce the symptoms of pain that occur in different parts of the body, such as dental pain, postoperative pain, and musculoskeletal pain.
• Migraines: Brexin medicine is sometimes used as a prophylactic treatment for migraines accompanied by nausea, vomiting, and sensitivity to light and sound.

How to take the Brexin medicine?

Before Brexin intake, follow these directions:

• Take your medicine at the same time(s) each day.
• Swallow the tablet whole, instead of crushing or chewing it.
• Avoid overdosing on the prescribed dose, as this can increase the risk of side effects.
• Do not stop taking Brexin without consulting with a healthcare provider, as stopping suddenly can worsen your health condition.
• Take this medication with a full glass of water, with or after food, to help prevent stomach upset.

What is Brexin tablet dosage?

The dosage of Brexin depends on several factors, especially the patient’s medical history and current medical condition. A healthcare provider may adjust the drug dose depending on individual response and tolerability. However, some general guidelines for Brexin dosage are as follows:

• The usual recommended dose for adults is 20 mg once daily.
• For children, the dose is based on weight and is usually 0.5 mg per kg of body weight twice daily. 
• For elderly patients, the dose may be reduced due to an increased risk of side effects.

Always consult a doctor before following this dosage.

What are Brexin side effects?

After Brexin intake, you may experience the following side effects: 

• Gastrointestinal problems — nausea, vomiting, stomach pain, heartburn, diarrhea, or constipation
• Skin rash or itching
• Fluid retention causing swelling in the legs, ankles, or feet
• Loss of appetite

More serious side effects of this medicine include: 

• Chest pain or breathing difficulty 
• Weakness on one side of the body
• Slurred speech
• Black, tarry stools or blood in the stool
• Yellowing of the skin or eyes
• Swelling of the face, tongue, or throat
• Severe skin reaction, including rash, blistering, or peeling

Contact your healthcare provider if you experience these side effects while taking this medicine.

What are the warnings associated with the Brexin?

Consider these warning signs before taking Brexin;

• If you suffer from gastrointestinal problems such as acid reflux or constipation, avoid taking this medicine as it will aggravate the symptoms.
• People already suffering from cardiovascular diseases such as coronary artery disease, hypertension, atherosclerosis, or arrhythmia should avoid this medicine.
• This medication might cause dry mouth, so drink plenty of water afterward.
• Brexin also causes headaches, therefore if you often experience migraine, avoid taking this drug.
• People suffering from sleep disorders, especially insomnia shouldn’t take this medicine as it affects the sleep cycle.

Does Brexin react with other medicines?

Brexin can interact with these medications:

• Blood thinners such as warfarin or heparin
• Other NSAIDs, such as aspirin, or naproxen
• Diuretics (water pills)
• ACE inhibitors, such as lisinopril or enalapril
• Angiotensin receptor blockers (ARBs), such as losartan or valsartan
• Lithium
• Methotrexate
• Cyclosporine
• Steroids, such as prednisone

Have a look at: Berica Tablet: Uses, Side Effects, and Price in Pakistan

What are the alternatives to Brexin tablet?

Use any of the following alternatives to Brexin if this medication is unavailable to you:

• Acetaminophen such as Tylenol
• Non-NSAID pain relievers including aspirin, ibuprofen, or naproxen
• COX-2 inhibitors like Celebrex or Mobic
• Topical analgesics including creams or gels such as Voltaren Gel and Lidocaine
• Steroids such as prednisone and dexamethasone

Probe into: Stomach Ulcer from Aspirin – Facts from Researches

What happens with a Brexin overdose?

Overdosage of Brexin might cause:

• Ringing in the ears
• Seizures
• Difficulty breathing
• Loss of consciousness
• Serious damage to the stomach and intestine leads to bleeding and perforation. 
• Damage to the kidneys and liver

What if you miss the Brexin dose?

Take the missed dose of Brexin as soon as you remember, but skip it if it’s almost time for the next dose. Don’t take a double dose to make up for the missed one.

How to store Brexin tablet?

Follow these instructions for storing Brexin:

• Properly dispose of expired or unused tablets.
• Keep your tablets out of reach of children and pets.
• Store Brexin medicine at room temperature between 20°C to 25°C.
• Do not use this medicine after the expiration date printed on the label or packaging.
• Keep the tablets in their original container or blister packaging until ready to use them.
• Do not store your tablets in the bathroom, near the kitchen sink, or in other damp or humid areas.
• Protect the tablets from moisture and light by keeping them in a dry place away from direct sunlight.

Is Brexin intake ok during pregnancy and lactation?

Pregnant women should avoid Brexin intake, as it can affect fetal development and increases the risks of developing birth defects. The medicine may also pass into the breast milk, therefore, nursing women should only take it after consulting a gynecologist. 

FAQs

1. Is Brexin used for fever?

Brexin is sometimes used for treating mild health issues such as nasal congestion, cough, runny nose, fever, and allergies, especially hay fever.

2. Can you take Brexin and ibuprofen together?

It is generally not recommended to take Brexin and Ibuprofen together without consulting a doctor. Both medications belong to the same drug class, and taking them together may increase the risks of developing gastrointestinal bleeding or kidney damage.