Danzol Capsule: Uses, Side Effects, and Price in Pakistan

Danzol capsule is a medication used to treat endometriosis, a condition characterized by the growth of endometrial tissue outside the uterus. It works by reducing the levels of estrogen and progesterone in the body, suppressing the immune system, and reducing inflammation to alleviate symptoms such as pain and discomfort due to endometriosis.

Manufactured by: Platinum Pharmaceuticals (Pvt) Ltd
Generic: Danazol
Drug Class: Androgenic hormones
Product form: Capsule

Mechanism of Action

The mechanism of action of Danazol involves the suppression of ovarian function, leading to a reduction in the levels of estrogen and progesterone in the body. This reduces the growth of endometrial tissue, suppresses the immune system, and reduces inflammation, thereby alleviating the symptoms of endometriosis.

Available Strengths

• Danzol Capsule 50 mg
• Danzol Capsule 100 mg
• Danzol Capsule 200 mg

What is Danzol Capsule Price in Pakistan?

Danzol Capsule 200mg price in Pakistan ranges between 40-50 PKR per capsule. The capsule price varies depending on the strength and manufacturer.

What is the Danzol Capsule used for?

The Danzol capsule uses include;

• Treatment of Endometriosis: Danzol is commonly used to treat endometriosis, a condition where tissue similar to the lining of the uterus grows outside the uterus, leading to pain and discomfort.
• Management of Painful Menstruation: It can be used to manage painful menstruation by reducing the severity and duration of menstrual cramps and reducing the amount of blood loss during menstruation.
• Prevention of Breast Cancer Recurrence: It has been shown to reduce the risk of breast cancer recurrence in some women who have undergone surgery and radiation therapy for breast cancer.
• Treatment of Hereditary Angioedema (HAE): It can be used to prevent attacks of hereditary angioedema, a rare genetic disorder that causes swelling in various parts of the body.
• Off-Label Uses: Danzol capsules can be used off-label for the treatment of other conditions such as fibrocystic breast disease, idiopathic thrombocytopenic purpura (ITP), and aplastic anemia. However, it is important to consult with a gynecologist before using Danzol for any off-label purpose.

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How to take the Danzol Capsule?

Here are some general guidelines on how to take Danzol Capsule:

• Danzol is taken orally by mouth with water.
• The dosage and duration of treatment will depend on the individual’s condition and response to the medication.
• Danzol is usually taken with food to improve absorption and minimize stomach upset.
• It is important to take Danzol at the same time every day to maintain a consistent level of medication in the bloodstream.
• Do not increase or decrease the dosage of Danzol without consulting a healthcare professional.

What is the Danzol Capsule dosage?

Here are some general guidelines on the dosage of Danazol Capsule:

• Dosage for Endometriosis: The typical starting dose for endometriosis is 200 mg daily, divided into two doses, for 6-9 months.
• Dosage for Painful Menstruation: The typical starting dose for painful menstruation is 100-200 mg daily, divided into two doses, for 3-6 months.
• Dosage for Breast Cancer Recurrence Prevention: The typical dosage for breast cancer recurrence prevention is 200 mg per day, divided into two or three doses, for up to 5 years.
• Dosage for Hereditary Angioedema: The typical starting dose for hereditary angioedema is 200 mg per day, divided into two doses, for 6 months to 1 year.

It is important to talk to a doctor before taking Danzol Capsule and to follow their recommended dosage instructions.

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What are Danzol Capsule’s side effects?

Here are some possible side effects of Danzol Capsule:

• Acne
• Oily skin
• Increased hair growth
• Voice changes
• Irregular menstrual periods
• Weight gain
• Nervousness or anxiety
• Decreased breast size
• Hot flashes
• Dizziness
• Insomnia
• Muscle cramps
• Joint pain
• Back pain
• Elevated liver enzymes
• Changes in cholesterol levels

If you experience any severe or persistent side effects after taking Danzol Capsule, stop its use immediately, and consult a doctor.

What are the warnings associated with the Danzol Capsule?

Here are some of the warnings associated with the Danzol capsule:

• Danzol capsules may cause liver damage or worsen existing liver disease.
• It may increase the risk of cardiovascular disease, including heart attack and stroke.
• These capsules may increase the risk of blood clots, including deep vein thrombosis (DVT) and pulmonary embolism (PE).
• It may affect blood sugar levels and may make diabetes worse.
• Danzol capsules may worsen symptoms of porphyria, a group of rare genetic disorders that affect the skin and nervous system.

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Does Danzol Capsule react with medicines?

Here are some medications that may interact with Danzol capsule:

• Warfarin
• Antidiabetic medications, such as insulin or metformin
• Cyclosporine
• Tacrolimus
• Theophylline
• Carbamazepine
• Phenytoin
• Rifampin

Is Danzol Capsule Safe during Pregnancy?

Danzol Capsule is classified as a pregnancy category X medication, which means it is contraindicated for use during pregnancy as it may cause fetal harm.

It’s important to consult a gynecologist if pregnancy is planned or suspected while taking Danzol Capsule. Effective contraception should be used by women of childbearing age during treatment with Danzol Capsule.

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What are the alternatives to the Danzol Capsule?

Some of the alternative brands for Danzol capsules are;

• Gonadotropin-releasing hormone (GnRH) agonists
• Progestins,
• Nonsteroidal anti-inflammatory drugs (NSAIDs)
• Icatibant
• Ecallantide

What happens with a Danzol Capsule Overdose?

An overdose of Danzol Capsule may lead to symptoms such as nausea, vomiting, abdominal pain, and dizziness. In severe cases, an overdose may cause increased intracranial pressure, fluid retention, and abnormal liver function tests.

What happens if you miss the Danzol dose?

If a dose of Danzol Capsule is missed, it should be taken as soon as possible. However, if it is close to the time for the next dose, the missed dose should be skipped and the regular dosing schedule resumed.

It is important not to take a double dose of Danzol Capsule to make up for a missed dose. If there are concerns or questions about missed doses, a healthcare professional should be consulted.

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How to store Danzol Capsule?

Here are some guidelines for storing Danzol capsules:

• Danzol Capsule should be stored at room temperature between 15°C and 30°C (59°F and 86°F).
• It should be kept in a tightly closed container, away from moisture, heat, and direct light.
• The medication should be kept out of reach of children and pets.
• Expired or unused Danzol Capsule should be properly disposed of according to local guidelines or through a medication take-back program.

If you have more questions about taking a Danzol capsule, consult a gynecologist.

FAQs

1. Can danazol cause menopause?

Although danazol is a weak androgen, it can cause symptoms that are similar to menopause because it decreases the secretion of LH and FSH.

2. Does danazol increase platelets?

Attenuated androgen danazol may help myelodysplastic syndromes (MDS) patients with their platelet counts in some cases.