Dexmedetomidine, a sedative commonly used in healthcare settings, is sold under the brand name Precedex. It is frequently used in hospitals and critical care settings for short-term sedation of adult patients who are on an artificial ventilator or undergoing surgical or other medical procedures.
Here is some information on Precedex’s applications, drawbacks, and cost in Pakistan:
Manufactured by: Pfizer Medical Information
Generic: Dexmedetomidine HCl 100mcg/mL; soln for IV infusions after dilution
Drug class: Sedatives
Product form: Single-dose vial, Single-dose glass bottle
Mechanism of Action
Precedex (dexmedetomidine) works by attaching to and activating alpha-2 adrenergic receptors in the brain, which causes a depressed central nervous system (CNS) and drowsiness. Dexmedetomidine has sedative effects because it is a selective alpha-2 adrenergic agonist, which means it specifically binds to and activates alpha-2 adrenergic receptors.
Norepinephrine, a neurotransmitter that carries nerve signals in the CNS, is not released when alpha-2 adrenergic receptors in the brain are activated. This causes the neuronal activity to decrease, drowsiness, analgesia (pain alleviation), and anxiolysis are the results (reduced anxiety). Precedex has sedative effects that are dose-dependent; greater doses cause deeper sleepiness.
What is the Price of Precedex in Pakistan?
Precedex Inj 100mcg/2ml cost in Pakistan ranges between PKR 800-850. It is available both online and at pharmacies. The cost of Precedex can vary depending on the manufacturer or the medicine’s strength.
What are the Uses of Precedex?
Precedex uses include;
- Sedation in Intensive Care Units (ICUs): Precedex is frequently used in ICUs to sedate patients who are on mechanical ventilation. Preserving a steady degree of sedation, it can assist decrease the need for additional sedative drugs and promote a more comfortable patient experience.
- Adjunct to Anesthesia: Precedex is frequently used as an adjuvant to anesthesia during surgical operations to give drowsiness and aid in pain management without causing respiratory depression. It may be especially helpful during operations where the patient must remain still, such as during some surgeries or diagnostic tests.
- Procedural Sedation: For procedural sedation, Precedex is utilized in emergency rooms and other places. It can be used to give sedation, analgesia, and anxiety relief for individuals undergoing minor surgery or other uncomfortable medical operations.
What are the Side Effects of Precedex?
Precedex side effects include:
- Low or high blood pressure
- Slow heart rate
- Abnormal heart rate
Who should not use Precedex?
The use of dexmedetomidine has no absolute limitations. However, because the medication may make bradycardia and hypotension worse, it is contraindicated in patients who already have these conditions.
How to store Precedex Injection?
The following are some details regarding the storage of Precedex;
- Keep this medication in a fridge between 36 and 46 °F.
- To protect it from light, keep this medication in the original container until you’re ready to use it.
- Protect the injection from direct sunlight and moisture.
- Do not freeze the injection.
What is the dosage for Precedex Injection?
Precedex injection is used on prescription only in the recommended dose based on the condition. The usual recommended dosage of Precedex is:
Injectable solution
- 200mcg/2mL (100mcg/mL) single-dose glass vial
- Requires further dilution before administering
Ready-to-use injectable solution
- 80mcg/20mL 0.9% NaCl (4mcg/mL)
- 200mcg/50mL 0.9% NaCl (4mcg/mL)
What are the Precautions associated with Precedex Injection?
Some of the warnings and precautions associated with the use of Predex include;
- Only individuals trained in patient management in an operating room or intensive care unit setting should administer Precedex.
- Patients should be closely watched while taking Precedex because of its known pharmacological side effects.
Does Precedex Injection interact with other medication?
The drug interactions of Precedex include:
- Svoflurane
- Isoflurane
- Propofol
- Alfentanil
It is important to inform your doctor about all the prescription, OTC, or herbal medicines that you are taking to avoid any serious complications.
What is the alternative to Precedex Injection?
The available alternatives for Precedex injection include;
- Midazolam
- Propofol
- Fentanyl
- Etomidate
It is always mandatory to consult an expert before using any kind of medication. Consult an anesthetist before using Precedex injection. If you want to take this medicine then do talk to an anesthetist.
FAQs
1. Does Precedex treat pain?
Numerous clinical studies have demonstrated that it can significantly lower the incidence of opioid-related adverse events and postoperative pain intensity.
2. How fast does Precedex work?
Precedex action onset occurs in less than 5 minutes, and its effect is at its peak in 15 minutes.
3. Why use Precedex instead of propofol?
Dexmedetomidine may be preferable to propofol for sedating ICU patients due to its potential to shorten hospital stays and reduce the risk of delirium.
Disclaimer: The content published on Marham.pk is for informational or educational purposes only, produced from FDA-approved literature, and does not substitute professional medical advice. Please consult your healthcare provider before using a prescription or over-the-counter drug, or any other treatment option.